Mohammad Reza Ahmadian

This study shows SIRT4 promotes autophagy by modulating ULK1 phosphorylation, independent of HDAC6 and OPA1, and identifies its role in early autophagy initiation.

This study characterizes the RAC1P29S mutation in melanoma, showing it hyperactivates signaling pathways by impairing GTP hydrolysis and altering effector interactions.

This study identifies SIRT4 as a specific interactor of C-RAF kinase, showing it suppresses MAPK signaling by stabilizing the inactive form of C-RAF.