Brett A. Duguay

This paper investigates how HSV-1 disrupts mitochondrial function through specific viral proteins, leading to changes that support viral replication while protecting mitochondria from degradation.

This study identifies eIF3d as essential for cholesterol biosynthesis required for KSHV lytic replication, showing its role in supporting translation of cholesterol-related host mRNAs.

This paper shows that increasing cholesterol efflux reduces herpesvirus replication by impairing nuclear egress.

This paper develops a yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses with an eighth sgRNA, enabling modular genome assembly and mutagenesis.

This paper identifies a phenothiazine urea derivative that inhibits both SARS-CoV-2 Mpro and PLpro proteases and shows broad antiviral activity against multiple human coronaviruses.