Trinity H. Tooley

This study shows that thapsigargin inhibits HCV infection by modulating lipid metabolism, affecting both RNA replication and viral egress through distinct mechanisms.

This study identifies PERK pathway activation as an antiviral mechanism against HCoV-229E and SARS-CoV-2 through chemical modulation of the unfolded protein response.

This paper develops a yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses with an eighth sgRNA, enabling modular genome assembly and mutagenesis.

This study identifies that cyclosporine A restricts HCoV-229E infection by inducing antiviral gene expression through interferon regulatory factor 1, independent of cyclophilin A/B or classical interferon responses.