Author

Alexander J. Bryer

University of DelawareORCID 0000-0002-2039-4778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Juan R. PerillaiD· 2 shared Akshay DeshpandeiD· 1 shared Ashwanth Christopher FrancisiD· 1 shared Cameron M. TorresiD· 1 shared Christopher AikeniD· 1 shared Itay Y. RoussoiD· 1 shared Jiong ShiiD· 1 shared Jonathan R. Andino-Moncada· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Juan R. PerillaORCID

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2 papers

Recent·Most cited

BiophysicsSmallPeer-reviewedAug 28, 2026

Stoichiometric binding of Cyclophilin-A to the HIV-1 capsid modulates its mechanoelastic properties

Juan S. Rey, Alexander J. Bryer, Juan R. Perilla

This study shows that CypA binding to HIV-1 capsids affects their mechanical properties, with higher stoichiometry increasing brittleness and reducing deformability.

DOI 10.1002/smll.75453

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiophysicsPLoS PathogensPeer-reviewedSep 11, 2024

Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection

Akshay Deshpande, Alexander J. Bryer, Jonathan R. Andino-Moncada…·Itay Y. Rousso

This study shows that HIV-1 core elasticity is essential for nuclear entry and infection, with capsid-targeting drugs reducing elasticity and impairing infectivity.

42 citationstop 3%

humanstructural biology

𝕏 PostBluesky