James P. Garifallou

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

The paper defines murine bone marrow mesenchymal and stromal cell progenitor identities and temporal emergence using a single cell atlas from fetal life to 18 months.

The paper shows that small variations in sperm miRNAs can influence embryonic gene expression and developmental outcomes through direct and secondary mechanisms.

This study identifies immune cell populations in the developing rat pancreas and spleen, showing IUGR disrupts their composition and is influenced by tissue environment and sex.

The paper shows that disrupting light cycles during a critical window reduces time-of-day protection from influenza, but rhythmic meal timing can compensate, highlighting the role of environmental cues in immune response.

The paper tracks GM-CSF expression in immune cells using reporter mice, identifying diverse sources and transient expression patterns in health and autoimmune neuroinflammation.

The paper uses in vitro hematopoiesis systems to analyze gene expression and chromatin organization during HPC formation, identifying genetic impacts on blood traits and disease.

This study identifies signaling pathways supporting nascent HSC release during EHT using single-cell RNA sequencing from human embryonic cells.

This study shows TPM1 deficiency promotes cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis in both human and mouse models.

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.