Author

Markus Höpfler

MRC Laboratory of Molecular BiologyORCID 0000-0002-2129-2220Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:protein design· 1

Frequent Co-Authors

Evangelia VartholomaiouiD· 2 shared Ivana GasiciD· 2 shared Ramanujan S. HegdeiD· 2 shared Alina BatiukiD· 1 shared Ana Coelho AlmeidaiD· 1 shared Aseem ShrivastavaiD· 1 shared Axel MogkiD· 1 shared Bernd BukauiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Evangelia VartholomaiouORCID

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3 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedSep 30, 2025

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male…·Bernd Bukau

This study identifies Apj1 and Ydj1 as J-domain proteins that regulate Hsf1 in distinct phases of the heat shock response in yeast.

1 citation

yeastexperimental assay

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Cell BiologyNature CommunicationsPeer-reviewedNov 17, 2024

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

Alina Batiuk, Markus Höpfler, Ana Coelho Almeida…·Ivana Gasic

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

15 citations

proteomicsexperimental assay

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Molecular BiologyMolecular CellPeer-reviewedJun 8, 2023

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation

Markus Höpfler, Eva Absmeier, Sew‐Yeu Peak‐Chew…·Ramanujan S. Hegde

The paper identifies how TTC5 recruits SCAPER to initiate tubulin mRNA degradation via interaction with the CCR4-NOT complex, linking ribosome-associated mRNA decay to microtubule regulation.

41 citationstop 5%

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