Axel Mogk

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

The paper presents the cryo-EM structure of the MecA/ClpC/ClpP complex from Staphylococcus aureus, revealing how MecA facilitates substrate transfer and how ClpC/ClpP interactions are regulated by ATPase activity.

This study identifies Apj1 and Ydj1 as J-domain proteins that regulate Hsf1 in distinct phases of the heat shock response in yeast.

The paper identifies two cooperating motifs in Roq1 that modulate Ubr1 activity, enhancing ubiquitination of both folded and misfolded proteins during proteotoxic stress.

This study identifies ClpL from Listeria monocytogenes as a potent AAA+ disaggregase that enhances heat resistance by efficiently solubilizing protein aggregates under severe stress.

The paper determines the structure of the ClpG disaggregase's N1 domain, revealing how it recognizes and binds protein aggregates through hydrophobic interactions and Zn2+ coordination.

This study shows that the Hsp70 disaggregation machinery disassembles Tau fibrils, generating small seeding-competent Tau species that can drive aggregation.

This study evaluates how green fluorescent protein (greenFP) maturation kinetics and proteasomal degradation affect tandem fluorescent protein timers (tFTs), identifying greenFPs that degrade efficiently and guidelines for tFT design.