Brian P. Delisle

This study shows that temperature cycles drive circadian regulation of the KCNH2 promoter through BMAL1:CLOCK binding at a conserved E-box.

This study shows light-cycle time-restricted feeding alters cardiac transcript usage in a sex-specific manner, revealing previously undetected transcript-level regulation.

This study shows that housing mice in thermoneutrality alters tissue-specific circadian gene expression without changing core clock genes.

This study uses molecular dynamics simulations to show that LQT2 mutations disrupt the selectivity filter structure, impairing channel trafficking, and that some variants can correct these defects.

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

This study shows feeding behavior affects RR and QT interval rhythms in mice through distinct mechanisms, with RR intervals linked to autonomic signaling and QT intervals to core body temperature.

This study uses machine learning and molecular dynamics simulations to predict which KCNH2 variants disrupt Kv11.1 channel trafficking, improving variant classification accuracy by ~10%.

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.