Volkhard Helms

The paper develops a random forest model to predict differential protein-protein interactions between experimental conditions using MINT embeddings and mass spectrometry data.

The paper identifies DCP2 as an ISR-induced transcript whose translation is regulated by an overlapping ORF that acts as an inhibitory element, which is relieved during stress.

This study characterizes the lipid composition of mammalian ER membranes using MemPrep, showing a common lipid profile across ER subdomains and linking lipid and protein biophysical properties.

Flavitransin inhibits dengue virus polyprotein insertion into the ER membrane, showing broad antiviral activity against flaviviruses.

This study investigates how different extracellular matrix proteins and substrate stiffness affect melanocyte differentiation and mechanosensation, revealing context-dependent MITF regulation.

This study tunes the material properties of transcription factor condensates to show their impact on gene expression levels in mammalian cells and mice.

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

The paper connects differential exon usage in developmental stages to changes in histone marks at exon boundaries across 19 human tissues and cultured cells.