Youngki You

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

This study uses cryo-EM and cross-linking to reveal the oligomeric structure of plant biotin carboxylase, showing asymmetric dimer-of-dimers and dynamic B-domain interactions.

PTMOverlay visualizes post-translational modifications across species by aligning PTM sites to protein sequences, revealing conserved modifications in bacterial central carbon metabolism.

This paper develops a genetic code expansion platform for in vivo study of lysine acetylation in non-model bacteria, demonstrating its use in a non-E. coli strain.

This study shows omega-3 fatty acids reduce CXCL9 expression in MIN6 cells via ARH3, potentially protecting beta cells from immune attack and preventing T1D.

The paper identifies conserved bacterial protein methylation, showing ribosomal protein L11 methylation regulates stringent response signaling and ribosomal homeostasis.

This study shows curcumin and its derivative didemethylcurcumin modulate proteasome activity in a concentration-dependent biphasic manner, with curcumin being more effective.