Uxoa Fernández‐Pelayo

This study shows that elevated cholesterol in APOE4 astrocytes causes mitochondrial cristae collapse and ATP synthase dysfunction, linking cholesterol imbalance to mitochondrial disease.

The paper shows that energy scarcity and mitochondrial translation impairment cause ALS-FTD-related proteins to form perinuclear stress granule clusters, potentially leading to pathological inclusions.