Abzer Kelminal Pakkir Mohamed Shah

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

The paper develops a functional metabolomics framework using synthetic microbial communities and computational analysis to track drug metabolism by gut microbes, identifying metabolites and their correlations with microbial taxa.

This study shows that Bacillus subtilis uses its extracellular matrix protein TasA to suppress Botrytis cinerea by disrupting fungal structures and delivering antimicrobial compounds, while the fungus responds with adaptive strategies.

This study identifies cyclo(Pro-Tyr) as a metabolite that disrupts eukaryotic cellular membranes by targeting Pma1 ATPase in microdomains, inducing oxidative stress and membrane fluidity changes in fungi and nematodes.