Sweta Vangaveti

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

Quercetin reduces toxic RNA levels and rescues MBNL-dependent mis-splicing in DM1 and DM2 models.

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

This paper introduces a method to temporally control CRISPR-Cas9 activity using bio-orthogonal chemistry, demonstrating its effectiveness in live cells and therapeutic applications.

This study shows that metal ions and temperature affect DNA nanostructure self-assembly, with divalent ions enabling assembly at lower temperatures and no adverse effects on cell viability.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

The paper identifies small molecules that reduce expanded CAG RNA abundance in SCA patient and mouse models, showing repeat-selective effects across multiple SCAs.

The paper uses molecular dynamics simulations to study how RNA modifications and magnesium ions affect tRNAPhe conformational dynamics in S. cerevisiae.

The paper shows that mutating two intronic nucleotides alters RNA structure and dynamics, disrupting MBNL1 and RBFOX1 regulation of INSR exon 11 splicing.