Christophe Rusniok

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

The paper characterizes avirulent P. aeruginosa strains lacking T3SS genes, showing they produce variable secondary metabolites despite low cytotoxicity.

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.