Jia He

This study uses genome and transcriptomic analyses of oat species to show that polyploidy creates functional redundancy, buffering mutations but hindering beneficial allele fixation, and proposes breeding strategies to overcome these challenges.

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

The paper introduces IsoVEM, a transformer-based algorithm for isotropic reconstruction in volume electron microscopy, improving axial resolution and repairing damaged sections.