Manuel Liebeke

This study identifies disaccharides as significant metabolites in alkane-oxidizing archaea and their bacterial partners, suggesting roles in energy storage and carbon cycling.

The paper uses spatial lipidomics to analyze the lipid profile of a parasitic bacterium in its native host tissue, revealing unique fatty acid adaptations.

This study shows predatory bacteria alter C. elegans microbiota, increasing vitamin B12 availability, which extends lifespan by suppressing a detoxification pathway.

This study identifies metabolic adaptations in sulfate-reducing bacteria (SRB) that enable their persistence in symbiosis with gutless marine worms, revealing a conserved core metabolism distinct from free-living relatives.

The paper identifies sphingolipids from a bacterial PKS as mediators of microbiota protection against pathogens in C. elegans.

This study examines how Atg16l1 deletion in intestinal epithelial cells affects fecal microbiota shifts during pregnancy in mice, identifying altered microbial composition and functional potential.

The paper identifies fucose-rich oligosaccharides in deep ocean seawater, showing their selective preservation compared to surface ocean samples.

The paper evaluates spatial metabolomics protocols and technologies, showing extensive metabolite coverage and comparable results across imaging MS methods.

The paper investigates carbon fixation efficiency in sulfur-oxidizing symbionts using single-cell analyses and metabolic modeling, finding that stored sulfur and polyhydroxyalkanoate contribute to energy and reducing equivalents for carbon fixation.

This study identifies differential regulation of degradation and immune pathways in the nematode Laxus oneistus under anoxic and hypoxic conditions.

The paper identifies two intracellular bacteria in Trichoplax H2, showing they live in symbiosis with the host and have distinct metabolic roles.

The paper introduces metaFISH, a spatial metabolomics pipeline that links host and microbial metabolites in situ, revealing metabolic adaptations and novel symbiosis metabolites in deep-sea mussels.

An open-source cloud engine annotates imaging mass spectrometry data at controlled false discovery rate; publicly shared results reached over 3200 datasets and 6 million metabolite images by January 2019.