David Shum

This paper develops recombinant tick-borne encephalitis viruses with reporter genes to guide antiviral testing, finding that Nluc is more stable than eGFP in certain conditions.

This study evaluates the antiproliferative effects of HHT and its derivatives against cancer cells, finding that they overcome MDR1-mediated resistance in some cell lines but are effective against primary leukemia cells.

The paper identifies and characterizes new structural scaffolds that modulate the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro, finding compounds with IC50 values ranging from 2.6 to 47 μM.

The paper performs an RNAi screen to identify host genes involved in Dengue virus infection, finding 1,730 genes that inhibit infection and 194 that enhance it, and identifies a common gene signature across multiple screens.

The paper identifies dsRNA-binding proteins that mediate decitabine's effects by stabilizing ERV RNAs, showing low Stau1 and TINCR expression correlates with poor treatment outcomes in AML patients.