Author

Hakim Djaballah

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6039-0181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Constantin Radu· 2 shared David ShumiD· 2 shared Paul A. Calder· 2 shared Bhavneet BhinderiD· 1 shared David Y. Gin· 1 shared Jeni P. Mahida· 1 shared Mark G. Frattini· 1 shared Vladimir Yong‐Gonzalez· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersPharmacology & Toxicology

Constantin Radu

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2 papers

Recent·Most cited

Pharmacology & ToxicologyCombinatorial Chemistry & High Throughput ScreeningPeer-reviewedOct 24, 2024

Antiproliferative Activity of Cephalotaxus Esters: Overcoming Chemoresistance in Cancer Therapy

Vladimir Yong‐Gonzalez, Constantin Radu, Paul A. Calder…·Hakim Djaballah

This study evaluates the antiproliferative effects of HHT and its derivatives against cancer cells, finding that they overcome MDR1-mediated resistance in some cell lines but are effective against primary leukemia cells.

1 citation

humanbulk RNA-seq

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Systems BiologybioRxivPreprintJul 12, 2022

An RNAi screen reveals common host-virus gene signatures: implication for anti-viral drug discovery

David Shum, Bhavneet Bhinder, Jeni P. Mahida…·Hakim Djaballah

The paper performs an RNAi screen to identify host genes involved in Dengue virus infection, finding 1,730 genes that inhibit infection and 194 that enhance it, and identifies a common gene signature across multiple screens.

DOI 10.1101/2022.07.12.496853

experimental assaydrug response / drug discovery

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