Jiliang Zhou

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

The paper develops a new Myh11-driven Cre mouse model for precise SMC-specific gene manipulation, avoiding issues of off-target activity and variable integration seen in existing models.

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

This study shows TEAD1 is essential for Schwann cell myelination, regeneration, and Remak bundle formation through mechanisms involving proliferation control and cholesterol biosynthesis.

The paper identifies CARMN as an evolutionarily conserved, smooth muscle cell-specific lncRNA, showing its down-regulation in vascular diseases and functional importance in maintaining the contractile phenotype of vascular smooth muscle cells.