David McDonald

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This study uses imaging mass cytometry to analyze changes in glioblastoma tumor microenvironment before and after treatment, finding increased normal brain cells and altered cellular interactions post-treatment.

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.

This paper develops an ex-vivo model of hepatocellular carcinoma using precision-cut tumour slices to enable efficient and ethical drug screening.

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

OPTIMAL benchmarks segmentation and analysis methods for Imaging Mass Cytometry data, identifying optimal parameters for cell type identification and spatial analysis.

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.