Conor Lawless

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

This study uses COX-SBFSEM to examine mitochondrial morphology and function in human muscle biopsies with mtDNA deletions, revealing distinct mitochondrial populations and spatial patterns of oxidative phosphorylation.

The paper shows that cell division reduces mtDNA mutation load in mitotic tissues of a mouse model, while post-mitotic tissues maintain stable mutation levels.

The paper systematically analyzes genetic interactions in budding yeast with telomere defects to understand the DNA damage response network and identifies a new role for Chk1 in telomere resection.