Amy E. Vincent

This study uses nanobiopsy and next-generation sequencing to assess subcellular mtDNA mutation loads in human tissue from mitochondrial disease patients.

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

This study uses COX-SBFSEM to examine mitochondrial morphology and function in human muscle biopsies with mtDNA deletions, revealing distinct mitochondrial populations and spatial patterns of oxidative phosphorylation.

This paper introduces a subcellular biopsy technology to isolate organelles like mitochondria from human tissue, demonstrating its ability to surpass the operational limit of laser capture microdissection.

This study maps mitochondrial morphology in different neuronal compartments of the aging mouse hippocampus using 3D electron microscopy, revealing age-related differences in mitochondrial structure across cell types.

This study shows psychological stress increases circulating cell-free mitochondrial DNA (ccf-mtDNA) in humans through glucocorticoid signaling, with no change in nuclear DNA levels.