Tue Sparholt Jørgensen

The paper reports a case of human infection with an ape-like Plasmodium vivax parasite, identified through whole-genome sequencing, suggesting zoonotic transmission from wild gorillas and chimpanzees.

The paper identifies a new PCR artifact called 'PCR leaping' and develops a DNA library screening method using it for natural product discovery.

The paper develops Telomore to recover missing telomeres in Streptomycetaceae genomes, increasing detection from 0% to 37% and identifying a new telomere-related protein family.

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

The paper provides over 1,000 high-quality Actinomycetia genomes, revealing genomic structures and biosynthetic gene cluster organization with ecological and biotechnological implications.

The paper analyzes 2,371 Streptomyces genomes to refine biosynthetic gene cluster (BGC) diversity using MASH-clusters and reveals conserved genomic structures suggesting vertical inheritance.

The paper evaluates metagenomic software tools using realistic datasets, highlighting improvements in assembly and taxon profiling while identifying remaining challenges in virus/archaea detection and reproducibility.

The paper develops CRISPR-BEST, a DSB-free base editing system for filamentous actinomycetes, achieving single-nucleotide resolution in Streptomyces species.

This paper presents the first whole genome sequence and mRNA transcriptome of the copepod Apocyclops royi, providing genomic resources for further study.

The paper reports the first genome and transcriptome of Acartia tonsa, revealing a 14-fold genome size difference among copepods and expanding genetic resources for evolutionary studies.

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.

The paper analyzes circular DNA elements in rat gut microbiomes from two environments, finding differences in element size and antibiotic resistance gene diversity linked to human impact.