Marius Walter

This study shows that the R2 mutation in UL37 of HSV-1 strain 17+ only partially blocks retrograde transport, allowing latency and reactivation in mouse models.

This study models HSV-1 dynamics in epithelial and neuronal cells under low and high MOI, revealing differences in eclipse phase duration, egress rates, and productive infection kinetics.

The paper maps X-linked gene reactivation and epigenetic silencing in developing PGCs, showing partial resistance to reactivation and enrichment of repressive marks.

This study shows that restricting meganuclease expression to specific tissues reduces off-target gene editing in vivo.

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

This study shows that DNA methylation is critical for restricting neural differentiation but not germline fate in ESCs, with TKO ESCs capable of germline specification.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

The paper shows that CTCF-mediated enhancer partitioning controls the promoter switch of Zdbf2 during exit from naïve pluripotency, independent of polycomb and DNA methylation.