SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium
Ian Mantel, Haoxuan Zhang, Juan Vargas…·Thomas Eisenhaure
SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.
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Washington University in St. LouisORCID 0000-0002-2514-3441Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Ian Mantel, Haoxuan Zhang, Juan Vargas…·Thomas Eisenhaure
SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.
Hope D. Welhaven, Joseph B. Lesnak, Kristin L. Lenz…·Kelsey H. Collins
The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.
Hrishikesh S. Kulkarni, Laneshia K. Tague, Daniel R. Calabrese…·Andrew E. Gelman
This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.
Elisha D. O. Roberson, Mary A. Carns, Li Hua Cao…·John Varga
The paper uses RNA-Seq to analyze SSc patient and control samples, identifying SPAG17 and SOX9 non-coding RNAs as novel factors in SSc pathogenesis.
Arthur S. Lee, Jannette Rusch, Abul Usmani…·Donald F. Conrad
The paper identifies CSMD1 variants linked to gonadal function in both sexes and shows that Csmd1 knockout mice have reproductive defects, implicating the complement system in postnatal development.