Smita S. Patel

This study develops a high-resolution assay to show that the replisome, composed of helicase and DNA polymerase, is a powerful torsional motor that regulates DNA replication stalling and reactivation.

The paper presents cryo-EM structures of human mitochondrial transcription initiation complexes, revealing mechanisms of start-site selection and slippage synthesis.

This study investigates how DNA polymerase interacts with the replication fork under stress and finds that prolonged stress inactivates replication and locks the fork, which is reversible only by helicase.