Solvig Diederichs

This study shows that heparin promotes endochondral differentiation of MSCs in vitro but chondral development in vivo, with selective anti-hypertrophic effects through SMAD2/3 regulation.

This study identifies distinct mechano-response genes regulated by load-activated FGFR and beta1 integrins in chondrocytes, showing they control different subsets of genes.

This study investigates the role of PGE2 in MSC chondrogenesis, showing it has chondroprotective effects despite being driven by prohypertrophic signals.

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.