Chien‐Lun Hung

This study shows LAT condensation gates PLCγ1 activation through bimodal LAT phosphorylation, enhancing signal amplification and noise suppression in T cells.

The paper shows that phosphorylation of TEL-ABL makes it resistant to asciminib, but dephosphorylation restores sensitivity.

The paper assesses BTK autoinhibition by substituting SH2 domains and finding that some substitutions enhance fitness by disrupting autoinhibition while maintaining phosphotyrosine targeting.

This study investigates whether BTK dimerization via its PH-TH module is required for signaling in B and T cells, finding it is not necessary in B cells but essential in T cells.