Sam Ghaffari-Kashani

This study quantifies biophysical trade-offs in antibody evolution by analyzing surface expression, affinity, and self-reactivity across 213 evolutionary intermediates of a SARS-CoV-2 antibody lineage.

The paper assesses BTK autoinhibition by substituting SH2 domains and finding that some substitutions enhance fitness by disrupting autoinhibition while maintaining phosphotyrosine targeting.

This study investigates whether BTK dimerization via its PH-TH module is required for signaling in B and T cells, finding it is not necessary in B cells but essential in T cells.