Tracy M. Handel

This study compares the conformational dynamics of ACKR3 and CXCR4 using MD simulations and BRET assays, revealing that ACKR3's dynamic behavior leads to activation-proneness and G protein-incompetence.

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

This study identifies N-terminal determinants of CCL27 and CCL28 receptor activation and selectivity by analyzing mutations and using AlphaFold models.

This study identifies a non-canonical activation mechanism of CCR9 by CCL25 through structural modeling and mutational analysis, revealing the 30s loop as the key activation region.

This study shows that delivering CXCL10 into tumors enhances immune cell infiltration, activation, and anti-tumor responses, and improves the effectiveness of immunotherapy in head and neck squamous cell carcinoma.

This study uses APEX2 proximity labeling and mass spectrometry to uncover ligand-dependent CCR5 trafficking mechanisms, revealing distinct internalization and degradation pathways.

This study develops and validates BRET-based assays to detect constitutive and ligand-dependent Gi-directed activity in GiPCRs, revealing novel regulatory mechanisms of Smoothened.

This study uses single-molecule FRET to compare conformational dynamics of CXCR4 and ACKR3, revealing distinct activation mechanisms and conformational landscapes.

This study identifies molecular determinants of CCR2 and CCR5 antagonist interactions using docking and AI screening, revealing structural principles and selectivity mechanisms.