Xiaoyun Yang

Archaeal ammonia monooxygenase (AMO) is a cup-shaped homotrimer using a mononuclear CuD site; inhibitors bind bacterial AMO's dicopper center directly but apparently inactivate archaeal AMO indirectly by relocating copper.

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

PepSeek identifies functional peptides using a combination of large language models and specialized models, achieving high accuracy in antimicrobial peptide discovery.