Cathy L. Miller

This study identifies packaging signals in mammalian orthoreovirus S gene segments, showing that terminal sequences including UTRs and ORF parts are critical for viral packaging.

This paper creates and characterizes a recombinant mammalian orthoreovirus expressing HER2 peptides to enhance oncolytic activity against HER2+ breast cancer cells.

This study shows that mammalian orthoreovirus (MRV) infects and kills HER2+ breast cancer cells, reduces HIF-1 accumulation, and may enhance trastuzumab efficacy.