Santiago Ruiz

This study shows nitazoxanide activates BMP9-ALK1-SMAD signaling and reduces HHT vascular abnormalities by modulating mTOR activity in endothelial cells.

A peptide vaccine targeting ANG2 reduces AVM number and size and normalizes vascular diameters in HHT mice without causing organ dysfunction.

The paper investigates the role of clock genes period and timeless in regulating synaptogenesis and rhythmic changes in synaptic bouton numbers in Drosophila motor neurons.

This study identifies CDK6-driven cell cycle acceleration in endothelial cells as a driver of arteriovenous malformations in HHT, suggesting CDK4/6 inhibitors as potential therapeutic options.