Kevin Hawthorne

The paper identifies subtype-intermediate progenitor cells in pancreatic cancer with distinct epigenetic profiles linked to clinical outcomes and lineage reprogramming.

The paper identifies spatially distinct epithelial states in PDAC that correlate with immunosuppressive myeloid niches and poor prognosis.

This study shows that HuR promotes immune evasion in PDAC by inhibiting T cell infiltration and function, suggesting HuR as a therapeutic target with immunotherapy.

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

This study shows that HuR in pancreatic cancer cells enhances angiogenesis by modulating extracellular vesicle signaling to endothelial cells, increasing their migratory and tube-forming abilities while reducing ICAM-1 expression.

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.