Rosanna Upstill‐Goddard

This study shows that sequential ATR and PARP inhibition can overcome acquired resistance to DNA damaging agents in pancreatic ductal adenocarcinoma.

This study identifies NDRG1 as a DNA repair protein that links pancreatic cancer stroma to chemoresistance by enhancing DNA damage repair through R-loop resolution.

This study shows that loss of wild-type Kras enhances oncogenic Kras signaling and promotes pancreatic ductal adenocarcinoma, while also increasing sensitivity to MEK1/2 inhibitors.

The paper identifies heterozygous frameshift variants in hnRNPA2B1 causing early-onset oculopharyngeal muscular dystrophy by altering nucleocytoplasmic transport.

This study shows FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs through ATAC-seq and RNA-seq integration.