Dominique Langin

The paper identifies the Col4a3-/- mouse as a model of CKD-associated cachexia, showing significant weight loss, muscle atrophy, and systemic inflammation.

This study shows that fatty acids from adipocyte lipolysis stimulate insulin secretion via FFAR4 and FFAR1 receptors, highlighting adipose-islet crosstalk in metabolic regulation.

This study shows hepatocyte ERα regulates sex-specific liver responses to fasting and feeding, affecting gene expression and metabolic pathways differently in males and females.

This study shows that short- and medium-chain fatty acids are preferentially oxidized within adipocytes rather than released, due to their distinct storage and mobilization dynamics compared to long-chain fatty acids.

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.