Hervé Guillou

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

This study shows hepatocyte ERα regulates sex-specific liver responses to fasting and feeding, affecting gene expression and metabolic pathways differently in males and females.

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

This study shows that ablating FGL1 in hepatocytes does not worsen MASLD or HCC, despite increased glucose and metabolic changes in western diet-fed mice.

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.

This study shows that juvenile protein restriction in mice reduces sexual dimorphism by affecting somatic growth, energy metabolism, and hepatic molecular identity, with distinct adaptations in reproductive development.

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

The paper shows that repeated fasting events sensitize enhancers and gene expression to enhance ketogenesis in mice.

This study shows that FGF19 and its analog Aldafermin cooperate with MYC to drive aggressive hepatocarcinogenesis in mice, raising concerns about the safety of Aldafermin in patients with compromised livers.

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.