Nikolaos Sfakianakis

This study develops macroscopic models to simulate cancer cell invasion and metastasis by bridging microscopic cell dynamics with continuum descriptions, showing accurate reproduction of phenotypic and spatial patterns.

The paper extends a cancer invasion model by incorporating stochastic N-cadherin bond lifetimes dependent on pulling force, predicting reduced motility and a transition between catch- and slip-bond behavior.

This study models cancer cell dormancy in mice using statistical distributions to predict reactivation times and survival dynamics, finding heavy-tailed and asymmetric distributions best fit dormancy patterns.

The paper enhances a hybrid multiscale cancer invasion model to better reflect biological dynamics and introduces a multi-organ metastasis framework.