William Harrison Hicks

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

This study develops matched patient-derived organoids and cell lines from melanoma brain metastases to evaluate responses to targeted therapies, finding both models respond to BRAF and MEK inhibitors.

This paper develops a method to assess cancer organoid viability using rapid imaging and a fragmentation algorithm, finding significant correlations between SSD scores and traditional viability markers.