João Botelho

This study shows that Rsm proteins regulate the K1-T6SS in Pseudomonas putida by repressing translation of T6SS components and effectors, and that their removal enhances T6SS activity and pathogen killing.

The paper analyzes DEF and anti-DEF gene dynamics across Enterobacteriaceae genomes, finding differences in turnover rates between chromosomal and mobile genetic elements.

This study shows that resistance variation and bacterial interactions influence the adaptation of a genetically diverse Pseudomonas aeruginosa population to antibiotic treatment.

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

The paper examines how defense systems affect horizontal gene transfer (HGT) across different timescales and finds that CRISPR-Cas most often reduces MGE abundance and gene acquisition, but this effect is masked by recent co-transfer events.

The paper studies how CRISPR-Cas immunity in the human gut microbiome affects phage abundances and bacterial diversity using longitudinal metagenomic data.