Jaime Iranzo

This study develops a stochastic model to investigate how CRISPR-Cas systems balance short-term and long-term antiviral defense, revealing three evolutionary regimes and spontaneous division of labor within CRISPR arrays.

The paper develops a mathematical model to explore why mobile genetic elements (MGEs) frequently carry defense systems, finding that the strength of inter-MGE interference determines whether these systems are beneficial or costly.

This study investigates how glyphosate resistance in bacteria affects the evolution and diversity of antimicrobial resistance genes.

The paper analyzes DEF and anti-DEF gene dynamics across Enterobacteriaceae genomes, finding differences in turnover rates between chromosomal and mobile genetic elements.

This study uses mathematical models to show that high-order synergistic interactions enhance stability in diverse microbial communities, suggesting their importance for engineered consortia.

This study examines prokaryotic genome evolution in the Movile Cave over 5.5 million years, finding reduced gene diversity, increased pseudogenization, and limited horizontal gene transfer.

The paper examines how defense systems affect horizontal gene transfer (HGT) across different timescales and finds that CRISPR-Cas most often reduces MGE abundance and gene acquisition, but this effect is masked by recent co-transfer events.

The paper studies how CRISPR-Cas immunity in the human gut microbiome affects phage abundances and bacterial diversity using longitudinal metagenomic data.

This study compares gene clustering criteria in prokaryotic pangenomes, showing that clustering methods significantly affect functional characterization and core genome inference, with methodological inconsistencies often exceeding ecological and phylogenetic effects.