Leif H. Oxburgh

This study shows that mitochondrial redistribution in developing proximal tubule cells depends on fluid flow and LRRK2 activity, which is regulated by shear stress.

This study identifies the roles of canonical and non-canonical Wnt signaling pathways in directing epithelial tubule interconnection during zebrafish kidney regeneration.

This study identifies HGF as a key inducer of epithelial tubule anastomosis in vitro and in embryonic kidneys, revealing a proliferation-independent mechanism involving MAPK and MMPs.

The paper shows that β-catenin modulates TCF/LEF binding at gene targets, switching from inhibitory to activating complexes during nephron progenitor cell differentiation.

This study shows that asynchronous mixing of kidney progenitor cells in organoids enhances nephrogenesis and functional features, but stromal overgrowth limits long-term study.

This study shows that TGFβ/Smad signaling controls interstitial cell proliferation in the neonatal kidney by inhibiting Wnt/β-catenin signaling to prevent over-proliferation.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.