Zongheng Wang

This study shows that mitochondrial DNA removal is essential for sperm development and activity, revealing a novel exonuclease, ExoA, required for mtDNA elimination and preventing nuclear-mito imbalance.

The paper identifies a transcriptional network regulating mitochondrial biogenesis in Drosophila by combining RNAi screening and ChIP-seq analysis, revealing key factors like CG1603 and YL-1.

This study identifies the PPR domain of POLRMT as an exoribonuclease essential for mtDNA replication and transcription proofreading in Drosophila and humans.

The paper investigates mtDNA selective inheritance in Drosophila, showing that developmentally-orchestrated mitochondrial processes like fission and transcription enable purifying selection against harmful mutations.

The paper shows that a JNK-insulin-Myc signaling relay activates electron transport chain biogenesis, ensuring sufficient mtDNA in Drosophila eggs and limiting deleterious mtDNA mutations.