Author

Zachary M. Hostetler

University of PennsylvaniaORCID 0000-0002-2830-8870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Christina M. HurleyiD· 2 shared E. James PeterssoniD· 2 shared Rahul M. KohliiD· 2 shared Yarra VenkateshiD· 2 shared Allen LiiD· 1 shared Chloe M. JonesiD· 1 shared Kushol GuptaiD· 1 shared Michael B. CoryiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

Christina M. HurleyORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 29, 2026

Genetic Code Expansion for Site-Specific Encoding of a Switchable, Intrinsic Fluorophore-Quencher Pair to Monitor Protein Dynamics

Priyanda Giri, Yarra Venkatesh, Moriah H. Mathis…·E. James Petersson

This paper introduces a genetic code expansion method to integrate a fluorophore-quencher pair into proteins for monitoring dynamics, demonstrating applications in studying protein function and drug screening.

DOI 10.64898/2026.06.26.734876

E. coliproteomics

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedMay 16, 2024

The LexA-RecA* structure reveals a lock-and-key mechanism for SOS activation

Michael B. Cory, Allen Li, Christina M. Hurley…·Rahul M. Kohli

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.

35 citationstop 4%

bacteria (other)structural biology

𝕏 PostBluesky