Christina M. Hurley

This paper introduces a genetic code expansion method to integrate a fluorophore-quencher pair into proteins for monitoring dynamics, demonstrating applications in studying protein function and drug screening.

The paper introduces an unnatural DNA base modification to map protein-DNA occupancy in non-CpG contexts, revealing binding patterns of LexA in bacterial promoters.

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.