Sylvain Moineau

This study identifies novel antiviral defense systems in Streptococcus thermophilus by analyzing genomic islands, revealing previously uncharacterized systems and highlighting their role as reservoirs of bacterial immunity.

This study analyzes microbial community changes in traditional Swiss cheese over 142 years, showing shifts linked to production practices and antibiotic use.

This study identifies 42 bacterial genes involved in Klebsiella phage infection using RB-TnSeq, revealing cross-family resistance and genus-specific gene dependencies.

This study isolates and characterizes nine new filamentous phages from Swiss-type cheeses infecting Propionibacterium freudenreichii, revealing sequence divergence, host range diversity, and CRISPR spacer targeting.

This study shows how endolysins adapt predictably through mutations that enhance substrate recognition, despite functional trade-offs and some variability in evolutionary paths.

This study identifies and validates 21 accessory defense systems in S. thermophilus, showing that some provide stronger phage resistance than CRISPR-Cas, especially when combined or expressed from plasmids.

This study examines microbial community stability and variability in water kefir, finding species-level stability but plasmid and phage diversity across generations and households.

This study identifies AbiV as an RNase in the bacterial antiphage system AbiV, revealing its structure, function, and mechanism of action.

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

The paper identifies four new 7-deazaguanine derivatives in phages and characterizes enzymes involved in their biosynthesis and insertion into DNA.

This paper engineers CRISPR-Cas9 variants from Streptococcus thermophilus to target diverse A-rich PAMs, enabling efficient genome editing in mice.