Author

Frank Oechslin

University of OttawaORCID 0000-0002-8473-8795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Assay:long-read sequencing· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Sylvain MoineauiD· 3 shared Vincent SomervilleiD· 2 shared Xiaojun ZhuiD· 2 shared Antoine CulotiD· 1 shared Aurélie NicolasiD· 1 shared Carlee MorencyiD· 1 shared Éric GuédoniD· 1 shared Julien JardiniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Sylvain MoineauORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 13, 2026

Isolation and characterization of novel filamentous phages from Swiss-type cheeses infecting the Gram-positive bacterium Propionibacterium freudenreichii

Noël Grosset, Aurélie Nicolas, Julien Jardin…·Éric Guédon

This study isolates and characterizes nine new filamentous phages from Swiss-type cheeses infecting Propionibacterium freudenreichii, revealing sequence divergence, host range diversity, and CRISPR spacer targeting.

DOI 10.64898/2026.07.11.737922

metagenomicsexperimental assay

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintMay 11, 2026

Predictable adaptive evolution of a phage endolysin through substrate recognition optimization

Xiaojun Zhu, Vincent Somerville, Rong Shi…·Frank Oechslin

This study shows how endolysins adapt predictably through mutations that enhance substrate recognition, despite functional trade-offs and some variability in evolutionary paths.

DOI 10.64898/2026.05.06.723369

long-read sequencingexperimental assay

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MicrobiologyMolecular Biology and EvolutionPeer-reviewedMar 1, 2024

Dairy practices select for thermostable endolysins in phages

Frank Oechslin, Xiaojun Zhu, Carlee Morency…·Sylvain Moineau

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

13 citations

bacteria (other)protein structure

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