Molecular BiologyJournal of Thrombosis and HaemostasisPeer-reviewed
Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm
Melissa A. Castiglione, Yaping Jiang, Christopher Mazzeo…·Huichun Zhan
This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.
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