Haoyi Zheng

This study characterizes heart failure in Tie2FF1 mice, showing left ventricular dilation, microvascular remodeling, and pulmonary/hepatic congestion without obstructive coronary disease.

This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.