Renjith Viswanathan

This study shows methionine oxidation in TDP-43's C-terminal domain disrupts structure and phase separation through region-specific mechanisms.

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

The paper shows CLAMP, a DNA-binding factor, regulates sex-specific splicing by interacting with RNA and modulating RBP dynamics.